inv(3)(p24q26) ?/MECOM

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Pleiotropic Contribution of MECOM and AVPR1A to Aggression and Subcortical Brain Volumes

Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands, Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center, Rotterdam, Netherlands, Department of Psychiatry, Erasmus Medical Center, Rotterdam, Netherlands, Department of Epidemiology, Eras...

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MECOM: Live migration of virtual machines by adaptively compressing memory pages

Live migration of virtual machines has been a powerful tool to facilitate system maintenance, load balancing, fault tolerance, and power-saving, especially in clusters or data centers. Although pre-copy is extensively used to migrate memory data of virtual machines, it cannot provide quick migration with low network overhead but leads to large performance degradation of virtual machine services...

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Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms

Clonal proliferation in myeloproliferative neoplasms (MPN) is driven by somatic mutations in JAK2, CALR or MPL, but the contribution of inherited factors is poorly characterized. Using a three-stage genome-wide association study of 3,437 MPN cases and 10,083 controls, we identify two SNPs with genome-wide significance in JAK2(V617F)-negative MPN: rs12339666 (JAK2; meta-analysis P=1.27 × 10(-10)...

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An unusual case of splenomegaly and increased lactate dehydrogenase heralding acute myeloid leukemia with eosinophilia and RUNX1–MECOM fusion transcripts

We report the first case of acute myeloid leukemia (AML) with RUNX1-MECOM fusion transcripts, showing marked eosinophilia. A 63-year old man admitted in August 2013, had previously been observed in April 2013, because of persisting homogeneous splenomegaly and increased LDH, which were initially attributed to both minor β-thalassemia and previous acute myocardial infarction. However, based upon...

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Germline variations at JAK2, TERT, HBS1L-MYB and MECOM and the risk of myeloproliferative neoplasms in Taiwanese population

Germline variations at JAK2, TERT, HBS1L-MYB and MECOM have been found to associate with myeloproliferative neoplasms (MPNs) in European populations. Whether these germline variations are associated with MPNs in Taiwanese population is obscure. Here we aimed to evaluate the association of five germline variations (JAK2 46/1 haplotype tagged by rs12343867, JAK2 intron 8 rs12339666, TERT rs273610...

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ژورنال

عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology

سال: 2018

ISSN: 1768-3262

DOI: 10.4267/2042/68237